Animal Health and Infectious Diseases

Animal Health and Infectious Diseases

Invasive aspergillosis

Document Type : Review

Authors
Narges Bastami 1
Majid Zarrin 2
1 Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2 Department of Medical Mycology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
10.22034/jahid.2024.710973
Abstract
Background and Aim: Invasive aspergillosis is a life-threatening fungal disease that causes high morbidity and
mortality in patients withsuppressed immune system. The most common Aspergillus species that cause invasive
aspergillosis are Aspergillus fumigatus, followed by Aspergillus terreus and Aspergillus flavus. Aspergillus can cause a
wide range of clinical syndromes from a simple colonization to an invasive form. The most common form of this disease is pulmonary aspergillosis, and Aspergillus fumigatus is the cause of most cases of pulmonary aspergillosis. Several pathogenic factors of Aspergillus fumigatus are known.Neutropenia is the mostcommon risk factor for this disease.
Despite the increasing prevalence of invasive aspergillosis, rapid, accurate diagnosis and treatment of this disease are
still important. Due to the wide range of non-specific clinical signs as well as the shortcomings of current diagnostic
techniques, most patients are diagnosed either as "possible" or "probable" cases. In addition, due to the lack of sensitive and specific tests, many high-risk patients received an experimental or long-term treatment of antifungal drugs that are also expensive, which led to drug-induced side effects and the possibility of fungal drug resistance going up. More accurate diagnostic techniques, along with targeted antifungal therapy, are essential requirements to reduce the morbidity and mortality of invasive aspergillosis.
Conclusion: In this review, invasive aspergillosis is surveyed in terms of causes, epidemiology, clinical forms,
diagnosis, and treatment. Also, the latest developments in the diagnosis tests and treatment of this infection are studied.
Keywords: Invasive aspergillosis, Aspergillusgenus, Aspergillus fumigatus, Diagnosis, Treatment
Keywords
Invasive aspergillosis
Aspergillusgenus
Aspergillus fumigatus
Diagnosis
Treatment
Subjects
 
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  • Receive Date 12 October 2023
  • Revise Date 12 November 2023
  • Accept Date 31 January 2024
  • First Publish Date 08 February 2024
  • Publish Date 21 December 2024