The poultry industry is one of the most significant strategic industries globally, with a direct connection to food security and the macroeconomic stability of various countries. Newcastle Disease (ND) is one of the most significant viral diseases in the poultry industry, representing a serious threat to poultry producers due to its highly contagious nature and substantial economic losses. This disease is caused by avian paramyxovirus type 1 (APMV-1) and, depending on the viral strain, can manifest a variety of clinical symptoms including respiratory, neurological, and gastrointestinal issues in poultry. Rapid transmission of the virus through bodily secretions, airborne particles, contaminated equipment, and wild birds complicates the control of this disease. Biosecurity strategies, such as quarantine, continuous disinfection, regulated entry and exit, and optimal management of feed and drinking water, play a crucial role in reducing the risk of disease outbreaks. Vaccination is recognized as one of the most effective control measures, employing various vaccine types including live, inactivated, and recombinant vaccines to immunize flocks. In addition, integrated management practices including continuous flock monitoring, the use of immune-boosting supplements, and prompt application of control measures during outbreaks significantly contribute to disease control. Besides traditional approaches, advancements in new-generation vaccines, nanovaccines, and the application of digital technologies for monitoring flock health have raised new hopes for more effective control of Newcastle Disease. Ultimately, meticulous implementation of prevention and control programs, continuous education of poultry producers, and adoption of innovative methods can substantially mitigate the economic impact of Newcastle Disease on the poultry industry. This article provides a review of methods for the prevention and control of Newcastle Disease.